Long term steroid hormone replacement therapy

‘Sick day rules’ give you advice about how to manage your usual tablet treatment if you are ill for another reason (for example, if you have ‘flu’).

Hydrocortisone is similar to cortisol, one of the body’s natural steroid hormones (chemical messengers). Cortisol is produced by the adrenal glands just above the kidneys) in response to instructions from the pituitary gland (at the base of the brain). It has many vital roles in maintaining normal healthy functioning, and is a very important part of the response to ‘stress’ of any kind, including illness.

The natural pattern of cortisol production results in high levels early in the morning, falling to very low levels in the evening and at night. Hydrocortisone replacement therapy is usually taken twice or three times a day. It can be taken on an empty stomach or with food. The largest dose is taken first thing in the morning, to mimic the natural rhythm as far a possible. You should not routinely take your hydrocortisone after 5pm, as this can disturb your sleep.

You are prescribed a low dose of hydrocortisone to replace what your body should make naturally. High doses of steroids taken for long periods of time can have side effects, but this is not the case with steroid hormone replacement therapy. It is not an ‘anabolic steroid’, of the type that is sometimes used I abused by athletes and body builders.

If your adrenal gland is not working properly (Addison’s disease) you usually also need to take fludrocortisone, which helps to regulate your salt and water balance. If your pituitary gland is not working properly, you may need a range of other types of hormone replacement therapy: your hospital specialist will assess this and advise you.

Very minor illnesses can be ignored. This section refers to illnesses such as bad colds or flu, and other illnesses causing a fever (high temperature).

Never stop taking your hydrocortisone. If you are ill (you have a fever, or feel you need to take time off work or stay in bed) you should double your dose of hydrocortisone until you feel better. This should be continued for as long as you are ill, then you can quickly go back to your normal dose. Taking a higher dose of hydrocortisone for a short time while you are ill is necessary and is not harmful. This is how your body would respond if you were able to make cortisol naturally. You do not need to change the doses of any other hormone tablets you take regularly. For more severe illnesses, you may need to triple your dose for a while: you should also see your GP that same day.